FASEB Journal (1995) 9(4):A9889.
Dual protective mechanisms of sodium butyrate and benzyl isothiocyanate in human colon cells: induction of detoxification enzymes and apoptosis.
Kirlin WG DeLong MJ Jones DP.
Emory University Sch. Medicine and Sch. Public Health. Atlanta GA 30322
The positive association of fruit and vegetables intake with lower incidences of colon cancer is thought to be due to the presence of both fiber and chemical inducers of NAD(P)H: quinone reductase (N:QR) and glutathione S-transferase (GST). A protective effect of fiber is production of butyric acid by microflora, which promotes cell differentiation... Cells lifting showed apoptotic characteristics of chromatin condensation and DNA fragmentation. These findings suggests a dual mechanism for cancer prevention by NaB and BIT. NaB enhances the effectiveness of dietary compounds, such as BIT, to induce detoxification enzymes and both promote the rate of apoptosis of damaged cells.
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