American Society of Preventive Oncology, 1
9th Annual Meeting,  March 8-11, 1995, Houston, TX, 1995. (1995)

Feasibility of increasing vegetables and fruit intake for colon cancer prevention
(Meeting abstract). Elmer PJ Fosdick L  Tharp TM  Smith SA  Laing B Potter J
Division of Epidemiology University of Minnesota Minneapolis.  MNl

Vegetables and fruit (V/F) are associated with lower colon cancer  risk. The protective effect of Vegetables and fruit may act through changes in levels of nutrients or other phytochemicals (antioxidants, fiber, indoles, phenols, etc), gut physiology, or hormone levels. Recent conflicting  data on the efficacy of antioxidant supplementation for cancer and cardiovascular disease prevention has heightened the need to investigate the effects of Vegetables and fruit intake separately from the study of nutrient supplements. A one year randomized clinical trial of  increasing Vegetables and fruit intake was conducted in pathology confirmed  adenomatous polyp patients... Serum levels of total carotenoids, beta-carotene,  alpha-carotene, and lutein were all significant in the Diet group as  compared to the Control group.. Lycopene and  cryptoxanthin increased in the Diet group but were not significantly different from the Control group. No between group differences were observed in serum tocopherol levels. These data support the reported  diet changes and indicate the magnitude of serum antioxidant changes  possible by increasing Vegetables and fruit intake. These diet changes were well accepted. No side effects were observed. Strategies used to increase  Vegetables and fruit will be reported. Results indicate that major changes in Vegetables and fruit intake can be achieved and maintained over

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